Inhibition of EPAC1 signaling pathway alters atrial electrophysiology and prevents atrial fibrillation

Thématiques :

Bastien GuillotArthur BoileveRichard Walton, Alexandre Harfoush, Caroline ConteYannis Sainte-MarieSabine CharronOlivier Bernus, Alice Recalde, Laurent SalléFabien Brette and Frank Lezoualc’h

Introduction: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with increased mortality and morbidity. The Exchange Protein directly Activated by cAMP (EPAC), has been implicated in pro-arrhythmic signaling pathways in the atria, but the underlying mechanisms remain unknown.

https://www.frontiersin.org/articles/10.3389/fphys.2023.1120336/full